Dr Thomas Seyfried - Metabolic Theory of Cancer

Dr Thomas Seyfried - American professor of biology, genetics, and biochemistry at Boston College

Disclaimer: This is not medical advice. Consult with a doctor before starting any treatment.

According to Seyfried, cancer is the result of chronic insults to oxidative phosphorylation, causing the cell to switch into a 2 billion year old mode of energy production called fermentation. This makes the cell proliferate, and use glucose and glutamine for fuel, while the dysfunctional oxidative phosphorylation produces high oxidative stress, driving mutations (as seen in tumors).

Dr Chatterjee interview

www.youtube.com/watch?v=MakS2iRkj1Q
Seyfried is working on the treatment protocol, but I believe it's something like:
1) get GKI (glucose ketone index) under 2 (7:1) with keto diet (no carbs)
2) water only fasting for more than a week
3) use glutamine lowering drugs
4) body starts autolytic cannibalism

GKI meter: keto-mojo.com

Some people have included turmeric and berberine.

BizNews interview

www.youtube.com/watch?v=2az_igDfXjQ
movie: Cancer Revolution
average 80yo glioblastoma survives 5 months
glioblastoma neoplastic cells use fermentation pathway to generate energy using glucose and glutamine
cancer is not genetic, it's metabolic
don't irradiate the brain as it frees up the fuels (glucose and glutamine)!
Paublo Kelly is still alive in England from glioblastoma without radiation or chemo
sugery is debulking and is important for glioblastoma
metabolic therapy can shrink the tumor by restricting glucose and glutamine
glioblastoma can't use fatty acids and ketone bodies
use ketosis diet, live 4 times longer
all cancers are driven by fermentation
ketosis allows small molecules through BBB
mitochondrial metabolic theory - Otto Warburg
damaged mitochondria produce ROS
glucose ferments into lactate
single cell hypoxic, bacteria gave us mitochondria allowing multicell, regulating energy metabolism
nucleus is a slave of the mitochondria
whole body tingled when I realised the consequence of this!
cancer cells can live in cianide
gene mutations are an effect of the damage to the oxidative phosphorylation
cancer cell's use of oxygen is to produce ROS which drives gene mutation
funded by private and philanthropy
ketogenic diet for epilepsy
origin of cancer is chronic damage to mitochondria and it's ability to produce energy through oxygen
if you keep your mitochondria healthy, cancer will be extremely rare
BRCA mutation damages oxidative phosphorylation
P53 mutation has 85% likelyhood of getting cancer

Jesse Chappus interview

www.youtube.com/watch?v=g4EY9WWuSR8
ultimatehealthpodcast.com/dr-thomas-seyfried-cancer
keto-mojo.com/glucose-ketone-index-gki Keto Mojo
glucose ketone GKI < 2 (keto mojo)
tumor cells use 
  glycolysis in the cytoplasm
  glutaminolysis in the mitochondria
growth = metabolites + energy
glutamine  is the most abundant amino acid in the body, and is synthesized from glucose
metastatic cells are derived from macrophages! But require glutamine
autolytic cannibalism
21 day water only fast 3 times a year to get rid of tumors
Guy Tenenbaum prostate cancer
doses/timing/schedule
never irradiate the brain for brain cancer

Protocol

With doctor supervision, first go on a ketogenic diet to lower glucose under 2 GKI (glucose ketone index, can be measured with a Keto Mojo meter). You will lose weight and your brain should function better and the tumors should shrink. Also need to pulse with a glutamine lowering drug. Low dose chemotherapy and/or debulking surgery may be needed if this doesn't eradicate all the tumors.