www.youtube.com/watch?v=oFmsMaTmBaY&t=2800
some people have a hyperinflammatory response to foreign DNA/RNA (activated STING pathway) gain of function in TORC1 causing hyperinflammation steroids and Treg lymphocytes turn off hyperinflammatory immune system rapamycin massively upregulates Treg lymphocytes Treg is a TORC2 cell totally healthy, very rich, high IQ are taking rapamycin off label and TORC2 upregulated in order to have a high IQ you have to have an upregulated TORC2 4mg rapamycin per day for graft vs host disease rheumotology world is funded by expensive biologics, so they're not taking up rapamycin as fast as they could says the FDA model is on it's way out for small molecule therapies. uses AI to find therapies for patients. chronic inhibition of mTORC1 (from high dose daily rapamycin) leads to indirect effects to mTORC2 (causing side effects) PI3K mice interfering RNA for TORC2, treats autism and epilepsy. mTORC2 inhibititors: lithium, high dose tamoxifen (PKC inhibitor) rapamycin can treat some depression synuclein is a predictor for alcoholism T cell response was so good, there wasn't enough innate immune activation to drive B cell antibody maturation If your innate immune system and T cells are cooking with gas, antibody testing is probably irrelevant people that never get sick, their immune system is perfectly tuned. rapamycin can clean out bad eggs to leave good ones for pregnancy eggs are full of mitochondria one patient took rapamycin and their endometriosis was fixed anesthesics (like xenon) work by effecting polarization of electron flow in mTORC1 anesthesic long term side effect is mitochondrial unfolded protein response