| Supplement | Outcomes |
|---|---|
| Alpha-Lipoic Acid | Increased levels of antioxidants |
| Improved sciatic functional index values | |
| Aided in healing and remyelinating damaged nerves | |
| Decrease oxidative stress | |
| Prevented degeneration of both axons and myelin | |
| Improved recovery of nerve function | |
| Increased nerve conduction velocity | |
| Curcumin | Reduced cell loss |
| Improved the action potential amplitude of the sciatic nerve | |
| Increased conduction velocity of motor neurons | |
| Improved mechanical sensitivity | |
| Improved motor and sensitive nerve conduction velocity | |
| Improved functional assessments | |
| Improved axonal regeneration | |
| Increase nerve myelination and therefore the diameter of nerve fibers | |
| Reduce reactive oxygen species, lipid peroxidation and cell death | |
| Expedited the reversal of mechanical allodynia | |
| Cytidine 5’-diphosphocholine (Citicoline/CDP-choline) | Decreased levels of MMP-2 and MMP-9 with increased levels of TIMP-1 and TIMP-3 |
| Decreased scar formation | |
| Decreased nerve adherence to surrounding tissue | |
| Improved sciatic nerve functional recovery | |
| Increased amplitude of the muscle action potential | |
| Increased axonal organization | |
| Increased axons, axonal density, and axonal myelination | |
| Decreased neuropathic pain | |
| EGCG | Improved axonal and myelin regeneration |
| Enhanced functional recovery | |
| Increased neuronal survival time after transection | |
| Reduced markers of oxidation | |
| Alleviated motor and sensory impairment | |
| Improved neuronal regeneration | |
| Melatonin | Improved structural preservation of the myelin sheaths |
| Increased malondialdehyde | |
| Improved functional outcomes | |
| Decreased nerve peroxidation | |
| Increased Schwann cell proliferation | |
| Increased nerve conduction velocity | |
| Increased axonal regeneration | |
| Reduced oxidative stress | |
| Improved neural regeneration | |
| Quercetin | Alleviating mechanical and thermal hypersensitivity |
| Enhanced axon remyelination | |
| Increased motor nerve conduction velocity | |
| Improved plantar muscle function | |
| Improved nerve regeneration | |
| Vitamin B12 | Augmented peripheral nerve regeneration |
| Improved toe-spreading reflex when combined with B1 and B6 | |
| Increased motor nerve conduction velocity when combined with vitamin E acetate | |
| Decreased the progression of thermal hyperalgesia when combined with vitamin E acetate | |
| Accelerated nerve regeneration | |
| Increased nerve myelination | |
| Improved motor and functional recovery of injured nerves | |
| Vitamin E | Increased functional motor neurons |
| Decreased nerve gliosis | |
| Improved sciatic nerve function | |
| Reduced muscle atrophy | |
| Decreased blood malondialdehyde levels and injury-induced 4-hydroxynonenal activity | |
| Decreased cold and mechanical allodynia | |
| Decreased Wallerian degeneration | |
| Reduced degeneration of motor nerve terminals when combined with selenium | |
| Preserved soleus muscle motor nerve terminals when combined with selenium | |
| Increased nerve conduction velocity | |
| Improved motor functional recovery | |
| Improved nerve regeneration |