www.youtube.com/watch?v=DT4HvUxFha4
mitochondria dysfunction drives aging all your mitochondira is 1% of you body weight all hallmarks of aging are downstream effects of less energy from mitochondria repair mechanisms use a lot of energy so when you lose energy, repair mechanisms are shut down repair mechanisms fix (not a full list): telomere length scenescent clearing mitrix.bio can measure mitrochondria for damage 25% mitochondrial damage is when things get bad kidney mitochondria damage is higher mitochondria are what consume the oxygen rapamycin was helping mitochondrial DNA is 16500 base pairs in a ring nuclear DNA is mutated 20 times slower than mitochondrial nuclear DNA replication is more accurate mitochondrial DNA is replicating constantly age 20-65: every 11 years you have twice as much mitochondrial DNA damage age 60 and older: every 3 years you have twice as much mitochondrial DNA damage Cramer's hypothesis: at 65, energy is too low and mitophagy gets shut off Cramer's book: How to Live Much Longer - The Mitochondrial DNA Connection Yamanaka factors use a lot of energy treatments in the meantime till the full therapy is available: -mitophagy therapy -rapamycin -periodic senolytics mitochondria have 34 genes. originally they had 2000, but most have migrated to nuclear DNA. of the remaining 34, only 13 are coding and are hydrophobic. being hydrophobic makes them hard to integrate into nuclear DNA and still work for the mitochondria. mitochondria DNA age 20 times faster than nuclear Cramer's muscle mass went up after being on rapamycin Cramer takes 6 mg rapamycin every 14 days Cramer did over a dozen HBOT sessions and got more energy Cramer thinks HBOT allows your mitochondria to make more ATP so you temporarily have more energy