www.youtube.com/watch?v=oFmsMaTmBaY
25% of people between 72 and 77 will have personality changes due to Alzheimers Alzheimers is a disease of mood as well as learning and memory first signs of Alzheimers is anxiety ATN profile: Amyloid, Tau, NFL (neurofilament light) biology is continuous, as such there is no specific dose for lithium lithium oritate endocrine system is systemic pericrine system is local microglia 6 synapses associated with Alzheimers mutations that allow cancer metastasize are mutations that produce local (pericrine) anti inflammatory signals that turn off tissue resident macrophages lithium carbonate is usually prescribed in psychology lithium oritate is used by naturopaths, dose: 40-50 if NFL isn't elevated, usually no atrophy on MRI (no cell death) lithium is more effective before neuron loss some (non bipolar) patients taking lithium say they think clearer and handle stress better lithium in bipolar patients dedifferentiates the astroglia lithium upregulates autophagy 50% of Alzheimers genes are microglia proximal cause is excitatory nerve cells a bunch of humans have a gain of function in TORC2 lithium is a targeted drug across many phenotypes because "lithium is hitting source code" lithium downregulates TORC2 causing cells to not senesce as quickly, and die cleanly through apoptosis nerve cells are postmitotic for a reason temporal lobe and olfactory lobe are the only regions that grow new nerve cells 25% of women have migraines 1% has epilepsy 10% will have an epileptic seizure lithium blocks final step adding iodine to thyroxine