London Futurists - Interventions to Trigger “Younging” Mechanisms: www.youtube.com/watch?v=mghDE-KWdeA
| Name | Description |
|---|---|
| M1 phenotype | Inflammatory macrophage |
| M2 phenotype | Anti-inflammatory macrophage |
| Microglia | Brain macrophages |
| CAP | Cholinergic anti-inflammatory pathway in the brain and spleen (acetylcholine) developed 150 million years ago to reduce circulating inflammation. |
| Factor | Function |
|---|---|
| NAD and sirtuins | Histone acetylation and methylation play important roles in longevity-related metabolic pathways |
| Klotho | Promoter region demethylation necessary for longevity benefits |
| Hypoxia / oxygen therapy | Varioxia leads to JMJD3 expression |
| Rapamycin / mTOR | mTOR pathway histone methylation patterns implicated in gliablastoma tumor cell proliferation |
| Integrated stress response (hypoxia, low amino acids) | ATF4 triggers JMJD3 expression |
| Vitamin D3 pathway | Activates JMJD3 |
| Blood borne longevity factors | Varioxia leads to JMJD3 expression |
| Blood factor dilution or addition rejuvenation | Implicates H3K27me3 reduction and CAP |
| Yamanaka factors (OSKM) epigenome reprogramming | All OSKM factors implicate JMJD3 / H3K27 |
| Alpha-ketoglutarate (AKG) supplementation | Increases JMJD3 |
| NRF2 | Copromoted along with JMJD3 |
| Autophagy | JMJD3 regulates expression of autophagy genes |
| Fasting | Induces JMJD3 |
| Heterochronic parabiosis | Induces JMJD3 |
| REM sleep | epigenetic health |
| Protein | Description |
|---|---|
| JMJD3 (Jumonji domain-containing protein-3) | Epigenetic regulating: histone demethylase regulating H3K27me3 |
| H3K27me3 | Trimethylation of histone H3 on lysine 27 |