ME/CFS itaconate shunt

Ron Davis - Stanford University Medical Center

ME/CFS causes:
  viral infection
  bacterial infection
  fungal infection
  parasite infection
  trauma
  surgery
  childbirth
activation of innate immunity
interferon alpha: upon activation of innate immunity, interferon alpha is produced that
  initiates the itaconate pathway in almost every cell
itaconate shunt: itaconate pathway is in mitochondria and decreases ATP production
CAD = cis-aconitate decarboxylase
interferon alpha and CAD triggers itaconate shunt
crashes might activate innate immunity
seems like crashing resets the disease. to cure the disease, don't trigger innate immunity
  for 1 year
crash = post-exertional malaise (PEM)
sicker patients are easier to crash
use interferon alpha inhibitor
looking for CAD inhibitors