Interleukin 11 (IL-11)

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan www.ncbi.nlm.nih.gov/pmc/articles/PMC11291288/

Stuart Cook & Jesús Gil www.youtube.com/watch?v=ImHuMpb1mpU

• turning off IL-11 gene improves aging diseases
• IL-11 is profibrotic & proinflammatory in the heart and kidney, etc.
• IL-11 stops tissues from regenerating properly
• IL-11 goes up with age in all tissues in mice
• IL-11 is inherited from fish
• IL-11 signalling inhibition alleviates: arthritis, multiple sclerosis, neointimal hyperplasia, multiple fibrotic diseases, and gastrointestinal cancers

IL-11 (& signalling) inhibitors

• Quercetin - abrogates STAT3
• Berberine - suppresses IL-11
• Sulforaphane - inhibits activity of NF-κB