Dementia "Protocol"

It comes down to what's driving the dementia. Need to look at other issues, like cardiovascular, or metabolic issues (diabetes, cancer, obesity), or sleep quality.

Dr. Bredesen - Dementia Protocol

Online cognition testing, brain training, dementia diet, personalized therapy to reverse dementia symptoms. www.apollohealthco.com

Homocysteine / B vitamins

First thing to do is make sure homocysteine is low. The higher it is, the faster the brain atrophy. Take active B complex, mainly B6, B9, B12. Dr. Joshua Miller: www.youtube.com/watch?v=sZoyPlJSgoQ

Spermidine

Spermidine can stop dementia progression. pubmed.ncbi.nlm.nih.gov/33211152

Creatine

Creatine monohydrate improves memory and cognitive performance. pubmed.ncbi.nlm.nih.gov/17828627

Infrared

There's a new infrared treatment that can reverse dementia by 1/5. Dr Paul Chazot: www.youtube.com/watch?v=JiidQ-k8cog

Inflammation

What's the CRP level, that indicates inflammation which usually is higher in old age. That should be lowered. jamanetwork.com/journals/jamaneurology/fullarticle/798950

Oxidative Stress

GlyNAC (glycine + N-acetyl-cysteine) boosts glutathione (antioxidant) in elderly which improves walking speed and cognition. www.bcm.edu/news/glynac-supplementation-reverses-aging-hallmarks-in-aging-humans

Senescence

Also the senescence load, that's indicated by p16 levels. Fisetin is a senolytic.

Genetics

Get a genetic test to see if there are any obvious genetic risk factors to focus on, and help guide personalized treatment. George Church is a legend. nebula.org

MoCA

A score of 16 is Alzheimer's, 22 is mild cognitive impairment, 30 is perfect. Can be given at home. championsforhealth.org/wp-content/uploads/2018/12/MOCA-8.1.8.2-English.pdf

Exercise

Exercise is important.

Diet

Mediterranean or FMD (Fasting Mimicking Diet) diets are generally the best. Omega-3 and lots of EVOO (extra virgin olive oil). EVOO might be one of the best ingredients to take. Prof. Valter Longo on FMD: www.youtube.com/watch?v=5N64Y3RTm3Y FMD: www.ncbi.nlm.nih.gov/pmc/articles/PMC10377404 olive oil: www.ncbi.nlm.nih.gov/pmc/articles/PMC10598670

Curcumin (Turmeric)

An all round ingredient to take. Anti-inflammatory and good for many things. www.scielo.br/j/babt/a/Dhgcy3dmSjX7wmjyQ34q9Yh

Anticholinergics

Don't be taking any anticholinergics. 3 years on anticholinergics is a 54% higher risk of dementia. Dr Leslie Kernisan: www.youtube.com/watch?v=16n80OQCVSM Need to boost acetylcholine to help with dementia. Helps with hippocampus for semantic and episodic memory. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645066 Here's a list of all anticholinergics: www.youtube.com/watch?v=16n80OQCVSM

Mood

If there's any depression or mood disorders, that can make dementia treatment more difficult so should be treated as well.

Cardiovascular

Maintain a healthy blood pressure to avoid vascular dementia. Take vitamin K2 to avoid aortic stiffness. Aortic stiffness can be measured at home with an iHeart, which can also measure HRV to show sympathetic nervous system activation. K2: www.ncbi.nlm.nih.gov/pmc/articles/PMC8308377 iHeart: goiheart.com HRV: pubmed.ncbi.nlm.nih.gov/28558638/

Hyperbaric Oxygen

Modern hyperbaric oxygen therapy (HBOT) for anti aging (and dementia) is pulsed to activate repair mechanisms. Pioneered in Israel, clinics are opening up in the US. The body triggers repair mechanisms in response to drops in oxygen levels (varioxia), this is why it has to be pulsed. Standard hyperbaric chambers used for divers are not pulsed. www.ncbi.nlm.nih.gov/pmc/articles/PMC7293997

EWOT

Exercise with oxygen therapy (EWOT) is similar to HBOT, but can be done at home for only a couple thousand dollars. All you need is an exercise machine (bike / treadmill / rower), a reservoir (bag), a mask and an oxygen concentrator. draxe.com/health/ewot-exercise-with-oxygen-therapy ewot.com

Novos

If you're looking for 1 supplement to take, Novos Core might be a good option. It includes 100mg of fisetin. novoslabs.com novoslabs.com/14-tips-to-reduce-your-risk-of-dementia-and-alzheimer-disease

Therapeutic Plasma Exchange (TPE)

Sometimes referred to as an oil change. TPE can slow Alzheimer's by 66%. www.diamandis.com/blog/young-blood-and-longevity-tpe