www.youtube.com/watch?v=vEyw_KrQp0I
C15:0 (pentadecanoic acid) first essential fatty acid to be discovered in 90 years C15:0 comes from whole fat dairy required for physiological health 250mg per day cell membrane pacemaker theory of aging cell membrane biliped layer, the stronger the fatty acids in the cell membrane, the longer the lifespan protect cells against lipid peroxidation longer, makes animal live longer higher saturation of C15:0 causes longer lifespan C15:0 targets: cellular senescence inflammaging mitochondrial dysfunction impaired cellular signaling 80% stronger cells 45% improved mitochondria 18+ anti-inflammatory activities 5 longevity signals declining hemoglobin with age is a biomarker for aging rate C15:0 restores healthy hemoglobin anti-inflammatory antifibrotic: breaks up aging related scar tissue in organs (fatty liver disease) antioxidant: protects against cellular lipid peroxidation anticancer: stops proliferation of 6 cancer cell types. reversed tamoxifen resistance in breast cancer cell lines antimicrobial: decreases proliferation of bad bacteria and fungi people with higher C15:0 levels have: -lower cholesterol, triglycerides, ApoA1 & ApoB -higher insulin sensitivity and B cell function -lower risk of impaired fasting glucose and impaired glucose tolerance -lower liver enzymes -lower risk of elevated blood pressure -lower BMI, body weight and waist & hip circumferance -lower CRP -lower adipokines -lower risk of type 2 diabetes -lower risk of CVD -lower risk of a first heart attack -lower risk of heart failure -lower risk of coronary heart disease -lower risk of NAFLD -lower risk of NASH -lower risk of many cancers -lower risk of Alzheimer's improves microbiome 5ug/m? C16:0 is pro inflammatory