Alzheimer's Types

increase in hs-CRP and/or other inflammatory markers (IL-6, IL-8, TNF-a, etc.)
reduction in A/G (albumin/globulin) ratio
increase in M1/M2 ratio, reduction in MFI (phagocytosis index)
ApoE4 is important risk factor
presentation is typically amnestic
hippocampal atrophy is common
seek causes of inflammation (leaky gut, AGEs, diet, poor oral hygiene, etc.)
diet: ketoflex 12/3
resveratrol
SIRT1 is a longevity and anti Alzheimer's gene
APOE4 binds to 1700 genes and turns them down, including SIRT1
DHA and acetylcholine for synapse formation
HBOT or EWOT
metabolism correlates with cognition

patients tend to be older than type 1 (70s, 80s)
typically amnestic presentation
reductions in trophic support
ApoE4 is a risk factor
hippocampal atrophy is common
severe difficulty retaining new information, but no issues organizing, calculating, dressing, speaking
hypoglycemic at night not good

a mix of type 1 and 2

20% of Alzheimer's, but contributes to 50% of all Alzheimer's
mostly women, usually after menopause
no family history or only when older
low triglycerides and/or zinc
HPA dysfunction
depression is common
parietal syndrome
related to lewy body dementia or Parkinson's
most difficult Alzheimer's to treat

treat like type 1
treat like CVD, reduce LDL
avoid statins
increase nitric oxide
ginkgo biloba

treat like type 2
reduce nicotinamide